Manzardo is out of the lineup for Monday's game against the Twins.
Manzardo will head to the bench for just the second time in July while the Guardians go with David Fry at first base and Rhys Hoskins at designated hitter. Over his last 13 games, Manzardo has gone just 3-for-41 (.073 average) with a 31.9 percent strikeout rate.