Manzardo is out of the lineup for Monday's game against the Tigers.
With a .958 OPS on the month, Manzardo has been one of the team's hottest hitters throughout May, but the Guardians will still look to shield him from left-handed pitching. He'll cede first base to Rhys Hoskins in the series opener in Detroit while southpaw Framber Valdez takes the hill for the Tigers.