Manzardo (shoulder) went 0-for-3 with a walk and a run scored for Cleveland's rookie-level Arizona Complex League affiliate on Friday.
Manzardo is beginning a rehab assignment after he had been out of action for over six weeks after sustaining an injury with Triple-A Durham while still in the Rays organization. The Guardians acquired Manzardo in the July 31 trade that sent Aaron Civale to Tampa Bay.