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Your Mariners and Athletics have a distinct advantage in Week 1 (March 20-31), provided your league's Week 1 includes the two-game series in Japan set to begin Wednesday at 5:35 am ET. 
And if you've already drafted, why wouldn't it? The whole season should count, darn it. It's not like you couldn't change your lineup later. The only "locked" players would be the ones on those two teams. 
No Fantasy GM should be denied a two-homer game for Khris Davis or a gem from Marco Gonzales. You make the investment, you reap the rewards. It's only fair. 
        
But back to that advantage: Because of that early series, those two teams would have six games in a modified Week 1 while every other would have three or four. So regardless of whatever pitching matchups their hitters might face when they return to the U.S., those hitters deserve preferential treatment when setting your lineups. Meanwhile, Gonzales, Yusei Kikuchi, Mike Fiers and Marco Estrada are the only pitchers with even a hope of a two-start week. 
It's a big deal and reason why you'll want to take a second look who you've positioned where before your head hits the pillow Tuesday night. 
        
Of course, "preferential treatment" doesn't mean "automatic start." Not every member of those lineups is an everyday player, after all. So let's go through one by one and determine who's worth locking in for the next 12 days, at least as far as the typical mixed league goes. 
 	Mariners 
 	Expected to contribute in Japan 
    
                
                                                                            
    
    
    
    
            
    
                                    
                    Dee Gordon
                
                    
                                                            
            2B
        
        
                            
        
                    
                Though not with as much conviction as in years past, you most likely drafted him to be your predominant speed source, and the two extra games makes him a no-brainer in points leagues as well.
            
        
             
 
    
    
                                    
                    Jay Bruce
                
                    
                                                                                                    
            NYY • RF • #30
        
        
                            
        
                    
                Frankly, there's no guarantee he isn't the one who sits for Ichiro Suzuki's last hurrah, and while he does appear to be over the plantar fasciitis that wrecked his 2018, it may not be enough to salvage matchups against lefties like Chris Sale, David Price and Eduardo Rodriguez when he's back in the States.
            
        
                                                                                    
    
            
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                    Edwin Encarnacion
                
                    
                                                                                                    
            CHW • 1B • #23
        
        
                            
        
                    
                He's in obvious decline and may not be regarded as must-start all season long, but with six games on tap, the choice is clear.
            
        
                                                                                    
    
            
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                    Domingo Santana
                
                    
                                                            
            RF
        
        
                            
        
                    
                I could be talked into starting him, especially since all the lefties in the Red Sox series only improve his chances of playing. But I'm still not convinced he'll be in the lineup for all six games, especially with Ichiro getting a ceremonial spot for the first two.
            
        
             
 
    
    
                                    
                    Omar Narvaez
                
                    
                                                                                
            HOU • C
        
        
                            
        
                    
                Not in a one-catcher league, anyway. It's still not clear exactly how he and backup David Freitas will divvy playing time, but seeing as Narvaez bats left-handed, those Red Sox matchups are ominous. Two-catcher leagues are a different story.
            
        
                                                                                    
    
            
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                    Ryon Healy
                
                    
                                                                                                    
            TB • 3B • #45
        
        
                            
        
                    
                He seems like a pretty safe bet to start all six games as the obvious fill-in for Kyle Seager, but he's also bad — and was against lefties last year, too. Desperation play only.
            
        
                                                                                    
    
            
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                    Ichiro Suzuki
                
                    
                                                                                                    
            SEA • RF • #51
        
        
                            
        
                    
                Call it a publicity stunt or just a gesture of goodwill, but Ichiro is there for the pomp and circumstance and not his actual play. He's expected to cede his roster spot when the Mariners return to the States.
            
        
                                                                                    
    
            
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                    Marco Gonzales
                
                    
                                                                                                    
            PIT • SP • #27
        
        
                            
        
                    
                The Athletics can hit a bit, and the dimensions of the Tokyo Dome are small. Gonzales does a good job keeping the ball on the ground, though, and is one of just a handful of pitchers with a shot at two starts this week.
            
        
                                                                                    
    
            
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                    Yusei Kikuchi
                
                    
                                                                                                    
            LAA • SP • #16
        
        
                            
        
                    
                He looked competent this spring and figures to offer the Mariners some length. The possibility of a two-start week pushes him over the top.
            
        
                                                                                    
    
            
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                    Hunter Strickland
                
                    
                                                                                                    
            LAA • RP • #60
        
        
                            
        
                    
                I'm actually fine with it, despite his unconvincing fit in the role. He's the undisputed source of saves in Seattle and will have two more shots at them than any other closer (apart from Blake Treinen) this week.
            
        
                                                                                    
    
            
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 	Others who may be 'locked' 
    
    
                                    
                    Mallex Smith
                
                    
                                                                                
            TOR • CF
        
        
                            
        
                    
                He'll presumably take Ichiro's place when the Mariners return to the states, but the health of his elbow is a big "if" in what for him would be only a normal-length week.
            
        
                                                                                    
    
            
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                    Daniel Vogelbach
                
                    
                                                                                                    
            TOR • 1B • #20
        
        
                            
        
                    
                It's between him, Bruce and Santana who sits for Ichiro and, later, Smith. Vogelbach is the least proven of the three.
            
        
                                                                                    
    
            
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                    Mike Leake
                
                    
                                                                                                    
            ARI • SP • #8
        
        
                            
        
                    
                Useful with the right matchups, but a one-start week against the Red Sox isn't that.
            
        
                                                                                    
    
            
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 	Athletics 
 	Expected to contribute in Japan 
    
    
                                    
                    Robbie Grossman
                
                    
                                                                                                    
            KC • CF • #8
        
        
                            
        
                    
                He could get on base a lot at the top of a quality lineup. But it's his one and only strength, and you could probably do better.
            
        
                                                                                    
    
            
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                    Matt Chapman
                
                    
                                                                                                    
            SF • 3B • #26
        
        
                            
        
                    
                Any concerns about his offseason thumb and shoulder surgeries he has alleviated with loud contact this spring.
            
        
                                                                                    
    
            
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                    Matt Olson
                
                    
                                                                                                    
            ATL • 1B • #28
        
        
                            
        
                    
                Opening against two lefties (Gonzales and Kikuchi) is less than ideal, but you didn't draft him to sit him, especially not when he's playing two extra games.
            
        
                                                                                    
    
            
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                    Stephen Piscotty
                
                    
                                                                                                    
            ATH • RF • #6
        
        
                            
        
                    
                You could make the case he was underrated in drafts, but even if he's normally a fringy starter in three-outfielder leagues, that certainly isn't the case with two extra games on the schedule.
            
        
                                                                                    
    
            
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                    Jurickson Profar
                
                    
                                                                                                    
            ATL • SS • #7
        
        
                            
        
                    
                Surely you can find a spot for him at one of the three positions where he's eligible. The volume this week will make up for whatever he lacks in impact.
            
        
                                                                                    
    
            
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                    Marcus Semien
                
                    
                                                                                                    
            TEX • SS • #2
        
        
                            
        
                    
                I guess? Look, you wouldn't sit Xander Bogaerts or someone equally studly for him, but two extra games is a nice boost, especially since the matchups against the Angels back home are pretty favorable.
            
        
                                                                                    
    
            
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                    Ramon Laureano
                
                    
                                                                                                    
            SD • RF • #5
        
        
                            
        
                    
                He's exactly the sort of fringe player who stands out when there's a disproportionate schedule, especially since there are elements of power and speed there. (Maybe not in a three-outfielder points league.)
            
        
                                                                                    
    
            
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                    Mike Fiers
                
                    
                                                                                                    
            ATH • RP • #50
        
        
                            
        
                    
                Probably worth it just for the likelihood he makes two starts. You hope for the "boom" end of boom-or-bust, and the matchups allow for it.
            
        
                                                                                    
    
            
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                    Marco Estrada
                
                    
                                                                                                    
            ATH • SP • #21
        
        
                            
        
                    
                Too much "bust" here to hope for any "boom," regardless of how many starts he's making.
            
        
                                                                                    
    
            
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                    Blake Treinen
                
                    
                                                                                                    
            LAD • RP • #49
        
        
                            
        
                    
                He's the sort of closer you keep starting even when he has fewer games, so you certainly don't sit him when he has more.
            
        
                                                                                    
    
            
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 	Others who may be 'locked' 
    
    
                                    
                    Frankie Montas
                
                    
                                                                                                    
            NYM • SP • #47
        
        
                            
        
                    
                Looks like he has a job following a terrific spring, but the big-league track record suggests this isn't the sort of gamble you take in Week 1.
            
        
                                                                                    
    
            
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                    Jesus Luzardo
                
                    
                                                                                                    
            PHI • RP • #44
        
        
                            
        
                    
                Maybe in leagues that begin on March 28, this recommendation will be different, but since we don't know if he has a job yet, you can't risk it.
            
        
                                                                                    
    
            
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