The Cubs designated Little for assignment Monday.
Little ended up being an odd man out for a spot on the 40-man roster after the Cubs brought Braxton Garrett, Tyrone Taylor, Clay Holmes (fibula) and Ryan Zeferjahn aboard in trades Monday. The 25-year-old lefty was up in the big leagues with the Cubs for a week in April but has otherwise spent the entire season in the minors, logging a 5.03 ERA and 1.68 WHIP in 39.1 innings between Triple-A Iowa and Double-A Knoxville.