Mayfield replaced shortstop Carlos Correa after Correa left Monday's game with back discomfort.
Mayfield started at second base to give Jose Altuve a break but needed to adjust when Correa departed after his first-inning at-bat. Correa is listed as day-to-day, so Mayfield, who was called up to replace injured utility infielder Aledmys Diaz (head), could get some at-bats while Correa mends.