Mayfield was recalled from Triple-A Salt Lake on Friday and will bat ninth and play third base against the Mariners.
Mayfield was optioned Friday but is back less than a week later with Anthony Rendon shut down for season-ending wrist surgery. Mayfield has slashed .194/.239/.284 in 22 games this season, which doesn't make a case for regular playing time, but he could start at the hot corner against lefties such as Friday's starter Robbie Ray.