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Two NFC South rivals square off in Week 10 action when the New Orleans Saints visit the Carolina Panthers. It's been a rough start to Kellen Moore's tenure as New Orleans' head coach as the Saints are 1-8 and are in contention to have the No. 1 overall pick in April's NFL Draft. The team recently made a change at quarterback, benching Spencer Rattler in favor of rookie Tyler Shough. As for the Panthers, they're 5-4 and are quietly playing good football. They beat the Green Bay Packers last week and have gotten a big boost offensively behind running back Rico Dowdle, who has 652 rushing yards over his last five games.

Kickoff from Bank of America Stadium is set for 1 p.m. ET, and the Panthers are 5.5-point favorites at home, according to the latest Saints vs. Panthers SportsLine consensus odds. The over/under for total points scored is 39.5. The Panthers are -254 money line favorites (risk $254 to win $100), while the Saints are +205 underdogs (wager $100 to win $205). Before you make any Saints vs. Panthers picks, make sure to check out what the SportsLine Projection Model has to say. 

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Where to watch Saints vs. Panthers on Sunday

When: Sunday, Nov. 9
Time: 1 p.m. ET
TV: FOX
Stream: Fubo
Follow along: CBS Sports App

Saints vs. Panthers betting preview

Odds: Panthers -5.5, over/under 39.5

The Panthers have won five of their last seven games and are quietly in the wild card conversation, while the Saints have mustered just a single win on the year to date. Carolina has been especially good at home, going 3-1. This is the first game the Panthers have been favored this season. Five of Carolina's nine games have gone Over, while only three of New Orleans' six have. The Panthers are 27th in scoring offense and the Saints are 31st. 

Click here to bet Saints vs. Panthers at FanDuel Sportsbook, where new users get $150 in bonus bets if their first bet of at least $5 wins:

Saints vs. Panthers SGP

  • Over 39.5 (-118, DraftKings)
  • Panthers -5.5 (-108, DraftKings)
  • Rico Dowdle anytime touchdown (-150, DraftKings)

Final odds: +493 at DraftKings (wager $100 to win $493)

Model's Saints vs. Panthers score prediction, picks

Despite the Saints' trend of Unders, the SportsLine Projection Model likes Over 39.5 as that hits in 57% of the model's 10,000 simulations. The Panthers have been great at home and outside of a 9-point showing in a 40-9 loss to Buffalo, Carolina has scored 27, 30 and 30 in its other three home games this season. 

Saints vs. Panthers score prediction: Panthers 24, Saints 20

Want more Week 10 NFL picks?

You've seen the model's best bets for New Orleans Saints vs. Carolina Panthers. Now, get against the spread, total and money-line picks for every Week 10 NFL game here, all from the model that's simulated every game 10,000 times.