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NFL Week 12 commences with the Buffalo Bills visiting the Houston Texans on 'Thursday Night Football' at 8:15 p.m. ET. Those involved in NFL DFS contests will gravitate towards making a Josh Allen and James Cook NFL DFS stack with the Bills being top-heavy, while under-the-radar options include Khalil Shakir and Ty Johnson. As for Houston, its top daily Fantasy football pick is Nico Collins, who has thrived no matter who has thrown him passes, but the Texans' running back pairing shouldn't be overlooked.

Veteran Nick Chubb may not be what he once was, but he can still move the chains and is a nice complement to Woody Marks. The rookie back is a good bet for double-digit touches every week, and he also won't set back your NFL DFS salary cap too much, thus allowing you to still include higher-priced players in TNF DFS lineups. Before making any NFL DFS picks for Bills vs. Texans on 'Thursday Night Football,' be sure to check out the NFL DFS advice, strategy, and stacks from SportsLine daily Fantasy expert Mike McClure. 

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McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him could be way up.

Now, McClure has turned his attention to Texans vs. Bills vs on 'Thursday Night Football' and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine. 

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Top NFL DFS picks for Bills vs. Texans

Part of McClure's NFL DFS strategy for 'Thursday Night Football' is Bills quarterback Josh Allen. The reigning MVP nearly single-handedly won many NFL DFS contests for whomever rostered him last week with 317 yards and three touchdowns through the air, plus 40 yards and three scores on the ground. Allen has multiple total touchdowns in all but one game this season and leads all quarterbacks in Fantasy points for the fourth time in his career. While Houston has an elite defense, it is susceptible on the ground to quarterbacks as each of the last three it faced had at least 33 rushing yards, despite each being less mobile than Allen. See who else to roster at SportsLine.

Another of McClure's NFL DFS picks is Texans tight end Dalton Schultz. He's come on strong as of late with Davis Mills under center, and that could still be the case on TNF with C.J. Stroud (concussion) working his way back. Schultz has at least six catches and 51 yards in each of the last three weeks, with one total touchdown. He's averaging 60.5 receiving yards over his last six games and is on pace to have career highs in both catches and yards this season. Buffalo hasn't faced many top-tier TEs this season, but Travis Kelce -- who has fewer targets and catches than Schultz in 2025 -- had 66 yards and 2-point score versus the Bills in Week 9. See more NFL DFS picks at SportsLine.

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How to set NFL DFS lineups for Texans vs. Bills

McClure is targeting another undervalued player who could explode for huge numbers on 'Thursday Night Football.' This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of McClure's NFL DFS picks, at SportsLine.

So who is Mike McClure including in his optimal NFL DFS lineups for 'Thursday Night Football', and which under-the-radar player offers huge value? Visit SportsLine now to see optimal NFL DFS picks, NFL DFS rankings, NFL DFS advice and NFL DFS stacks, all from a daily Fantasy expert with more than $2 million in winnings, and find out.