How to bet on NFL Week 5: Where to bet, best betting sites, promos for Patriots vs. Bills on SNF

Sunday's NFL schedule wraps up with an AFC East battle featuring the Buffalo Bills and New England Patriots. According to the latest NFL odds, the Bills are favored by 8.5 points, while the over/under for total points scored is 49.5. The Week 5 NFL slate concludes with Jaguars (+3.5) vs. Chiefs on Monday Night Football.  

Bettors looking for sportsbook promos, betting sites, and where to bet on the NFL for Week 5 can read more below, along with picks for some of the biggest games. 

Sportsbook offers

Here are the top sportsbook promos for new users ahead of the 2025 Week 5 NFL schedule.

The DraftKings promo code, bet365 bonus code and FanDuel promo code all offer bonus bets after new users place a wager of $5 or more. DraftKings offers $200 in bonus bets if your first bet of at least $5 wins. The FanDuel promo code provides new users $300 in bonus bets if their first bet of $5 or more wins, while the bet365 bonus code CBSBET365 offers $200 in bonus bets with a $5 wager, whether it wins or loses.

Both the Fanatics Sportsbook promo code and BetMGM bonus code provide bonus bets, but only if your first bet loses. Fanatics is offering new users the ability to get $100 in FanCash plus $100 No Sweat Bets in FanCash on every football Game Day until October. However, users in New York are limited to $25 in No Sweat Bets in FanCash. Using the BetMGM bonus code CBSSPORTS gives new users up to $1,500 back in bonus bets if their first bet loses. BetMGM users in West Virginia, New Jersey, Pennsylvania or Michigan can get a different promotion and claim $150 in bonus bets if you win your first bet of $10 or more. 

The Caesars Sportsbook promo code is different than the others, providing profit boosts instead of bonus bets. After placing a wager of at least $1, you receive 20 100% profit boost tokens with the code CBS20X.

Betting on Week 5 of the 2025 NFL season

SportsLine's computer model simulates every NFL game 10,000 times. Since its inception, it has generated a betting profit of well over $7,000 for $100 players on top-rated NFL picks. The model is on a sizzling 39-19 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Bills -8.5 vs. Patriots

Buffalo has raced out to a 4-0 start this season, so the crowd support and motivation will be high heading into this primetime divisional matchup. Bills quarterback Josh Allen has already thrown for 964 yards and seven touchdowns while rushing for 159 yards and three more scores. New England took care of business at home against Carolina in Week 4, but this will be its toughest opponent yet by far. The model does not think the Patriots stack up in this matchup, as the Bills are covering the large spread in 66% of simulations. 

Jaguars +3.5 vs. Chiefs

The Jaguars are coming off an impressive 26-21 win on the road against San Francisco. Running back Travis Etienne Jr. had a productive performance in the win, recording 19 carries for 124 yards and one touchdown. The Jags are 5-1 against the spread in their last six games, while the Chiefs are 6-12 ATS in their previous 18 games. The model predicts a close game on Monday night, with Jacksonville covering the spread in 52% of simulations. 

Responsible gaming

Responsible gaming is extremely important, which is why sportsbooks provide tools such as wager limits to help out their users. National resources are also available for bettors, including The National Council on Problem Gaming, Gamblers Anonymous, and 1-800-GAMBLER.