Chargers vs. Steelers prediction, odds, line, time: NFL Week 10 'Sunday Night Football' picks by proven model

A pair of AFC contenders clash when the Pittsburgh Steelers meet the Los Angeles Chargers on 'Sunday Night Football.' Pittsburgh is coming off a 27-20 win over the Indianapolis Colts in Week 9, while Los Angeles topped Tennessee 27-20. The Steelers (5-3), who lead the AFC North by two games, are 2-1 on the road this year. The Chargers (6-3), who are second in the AFC West, are 3-2 on their home field. Chargers starting offensive tackle Joe Alt (ankle) was put on injured reserve after going down last week against the Titans. 

Kickoff from SoFi Stadium in Inglewood, Calif., is set for 8:20 p.m. ET. The Steelers lead the all-time series 25-11, and have won two of the last three meetings. The Chargers are 2.5-point favorites in the latest Steelers vs. Chargers odds, while the over/under for total points scored is 44.5 via SportsLine consensus. Before making any Chargers vs. Steelers picks, check out the NFL predictions from the SportsLine Projection Model. 

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The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 on a sizzling 47-29 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on Steelers vs. Chargers. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Chargers vs. Steelers:

Why the Chargers can cover

Veteran quarterback Justin Herbert powers the Los Angeles offense. In nine starts this season, he has completed 220 of 325 passes (67.7%) for 2,390 yards and 18 touchdowns with eight interceptions and a rating of 97.3. He has also rushed 46 times for 305 yards (6.6 average) and one touchdown. In the win over the Titans, he completed 19 of 29 passes for 250 yards and two touchdowns with one pick. He also carried nine times for 57 yards and a score.

Among his top targets has been Ladd McConkey. The second-year wide receiver has played in nine games and has 47 receptions for 524 yards (11.1 average) and three touchdowns. He has had five explosive plays of 20 yards or more, including a long of 42, with 193 yards after the catch and 25 first-down conversions. In a 29-27 win at Miami on Oct. 12, he caught seven passes for 100 yards and one touchdown. See which team to back at SportsLine. 

Why the Steelers can cover

The Pittsburgh offense is led by veteran quarterback Aaron Rodgers. The future Hall of Famer has completed 167 of 243 passes (68.7%) for 1,692 yards and 17 touchdowns with five interceptions. In the win over the Colts, he completed 25 of 35 passes for 203 yards and one touchdown. He completed 24 of 36 passes for 219 yards and two touchdowns in a 35-25 loss to the Green Bay Packers on Oct. 26.

Among Rodgers' top targets is wide receiver D.K. Metcalf. In eight games, he has 29 receptions for 467 yards (16.1 average) and five touchdowns. He has nine explosive plays of 20 yards or more, including a long of 80 with 275 yards after the catch and 21 first-down conversions. In a 24-21 win over the Minnesota Vikings in Dublin, Ireland, he caught five passes for 126 yards and one touchdown. See which team to back at SportsLine.

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How to make Steelers vs. Chargers picks

SportsLine's model is going Over on the total, projecting 47 combined points. It also says one side of the spread hits in well over 50% of simulations. You can only get the pick at SportsLine. 

So who wins Steelers vs. Chargers, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Steelers vs. Chargers spread to jump on, all from the advanced model that finished up over $7,000 on its NFL picks since its inception, and find out.