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Wednesday brings about two more second-round games for the 2026 NBA Playoffs, as the Minnesota Timberwolves enter Game 2 with a 1-0 lead over the San Antonio Spurs as Anthony Edwards surprisingly played and scored 18 points in a 104-102 win. The other game of the night is between the New York Knicks and Philadelphia 76ers. New York won 137-98 thanks to a 35-point performance from star guard Jalen Brunson. 

The SportsLine Projection Model, which simulates every NBA game 10,000 times, has issued its NBA best bets for Wednesday's pair of Game 2s. The model is on a great run, returning well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered the second round of the 2026 NBA playoffs on a sizzling 26-9 roll (74%) on top-rated NBA spread picks this season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.

See the FanDuel promo code for a new-user offer before placing any NBA Playoffs bets on Wednesday.

NBA Playoffs picks, best bets for Wednesday, May 6

  • Knicks -10.5 vs. 76ers
  • Jalen Brunson Over 6.5 Assists
  • Timberwolves-Spurs Over 215.5
  • Julius Randle Over 22.5 points + assists

Knicks -10.5 vs. 76ers

This was initially a 7.5-point spread, but it's shifted in New York's favor with the news that Philly big man Joel Embiid is out for Game 2. Even when Embiid played in Game 1, the Knicks had no issues, winning by a whopping 39 points to kick off this second-round series. The 76ers had no answers defensively, and New York cruised to an easy victory at home. The Knicks host Game 2 on Wednesday and will look to take a commanding 2-0 lead before things move to Philly. The model thinks New York will win again, and the model has the Knicks covering in the majority of simulations.  

Jalen Brunson Over 6.5 assists

Brunson took over in Game 1, dropping 35 points in 31 minutes as the Knicks had no problems dismantling the Sixers in Game 1. New York's star guard had just three assists in Game 1 as his focus was on getting buckets, and that certainly worked out fine. For Game 2, however, the model thinks Brunson will distribute the rock more often, pegging him to go Over 6.5 assists with a projection of 7.4. Brunson went Over 6.5 assists in four of New York's six first-round games against the Atlanta Hawks.  

Timberwolves-Spurs Over 215.5

Minnesota stole Game 1 in San Antonio 104-102 in a rather low-scoring affair. The total for Game 2 is set at 215.5, but the model expects these Western Conference foes to go Over here. The Over hits in more than 60% of simulations for an 'A' grade, though it's worth noting each team has leaned to the Under this year -- both in the regular season and postseason.  

Julius Randle Over 22.5 points + assists

Randle has cleared this line in four of his seven postseason games this year, including Game 1 against the Spurs. With Edwards operating at less than 100% in terms of health, Randle was a go-to guy for Minnesota, playing 41 minutes and scoring 21 points to go along with two assists and 10 rebounds. The model thinks Randle is in line for another big game on Wednesday with a projection of 26.3 total points + assists.