The Tigers placed first baseman Miguel Cabrera on the 15-day disabled list because of a strained left calf on Saturday, the team announced via Twitter.
Cabrera -- on the disabled list for the first time in his career -- left Friday's game against the Blue Jays in the fourth inning while running the bases. He was 2 for 2 with a RBI prior to the injury.
Detroit will be without Cabrera for an estimated six weeks after the slugger was diagnosed with a Grade 3 calf strain on Saturday.
Cabrera is hitting .350 with 15 home runs and 54 RBI in 277 at-bats this season.