Free MLB home run picks, odds for Sept. 26: Juan Soto among best bets for Friday HR player props

The New York Mets are desperately trying to hold onto the final National League wild-card berth heading into their series opener against the Miami Marlins on Friday night. Marlins pitcher Sandy Alcantara is just 10-12 with a 5.48 ERA this season, but he is 2-0 with a 2.25 ERA in two starts against the Mets in 2025. Mets slugger Juan Soto homered for the 43rd time this season on Wednesday against the Cubs, giving him eight long balls this month. Soto has two homers in his career against Alcantara, and he is +360 to go yard in the Friday MLB odds. 

SportsLine's Inside the Lines team is including Soto in their Friday MLB HR bets. MLB home run props are available for almost every player in every game at various sportsbooks, and SportsLine's proven computer model can help you find value for your MLB betting picks. New users can also use the latest DraftKings promo code to get $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket, and take advantage of one of the best sportsbook promos:

The SportsLine Projection Model simulates every MLB game 10,000 times. It's up 28.6 units on its individual MLB HR picks this season after calling Vinnie Pasquantino (+455) and Francisco Lindor (+420) to homer on Thursday, and it has hit two three-leg parlays paying at least 80-1. Now, the model and SportsLine's team of Data Scientists have revealed their betting projections for some of the most-bet MLB HR prop bets on Friday. You can find even more picks in their daily blog.

Best MLB home run picks for Friday, September 26:

• Colson Montgomery, White Sox (+500)
• Byron Buxton, Twins (+327)
• Juan Soto, Mets (+360)
• Parlay these picks for +10940 odds at BetMGM (odds subject to change)

MLB Best Home Run Bets 9/26

For more real-time, free picks every day: Inside the Lines Blog.

Colson Montgomery, White Sox (+500, BetMGM)

Montgomery is coming off back-to-back two-hit games and is riding a 7-game hit streak. The rookie has 19 HRs in just 68 games played this season, with 16 of those coming against right-handed pitchers, along with an .873 OPS. While Cade Cavalli has been better against lefties, 4 of the 6 HRs he's allowed have come from left-handed batters. We set Montgomery's line at +370 to homer. You can get up to $150 in bonus bets if your first $10 bet wins at BetMGM:  

Byron Buxton, Twins (+327, FanDuel)

Buxton is swinging a red-hot bat, with 3 HRs over his last two games played. He only has three career ABs against Aaron Nola despite both being in the majors for a long time, and he's 1-for-3 with a double. Nola is having the worst year of his career and has allowed 10 HRs in 8 home starts. We set the line at +250 for Buxton to homer, and you can use the latest FanDuel promo code to bet this prop and get $300 in bonus bets if your first wager of $5 or more wins:

Juan Soto, Mets (+360, BetMGM)

Soto is a solid 12-for-43 with 2 HRs in his career against Sandy Alcantara. Despite going 0-for-5 yesterday, Soto has been swinging a hot bat, hitting 11 home runs over his last 25 games played. We set the line at +315 for Soto to homer, and you can get up to $150 in bonus bets if your first $10 bet wins at BetMGM:

Where to bet MLB props on Friday

Here is a look at betting sites that will offer MLB HR props on Friday: 

More MLB picks for Friday 

You've seen the model's MLB HR prop picks for several players on Friday. Now, get MLB projections for every player prop at SportsLine.

Need more from SportsLine? See today's best MLB picks from SportsLine's Angelo Magliocca, who is on an 83-58-1 roll (+1743.5) on MLB picks.