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Saquon Barkley RB | PHI
Giants' Saquon Barkley: Handles 28 touches in return
Barkley (ankle) had 24 carries for 93 yards while catching four of five targets for five yards in Sunday's 14-9 loss to Buffalo.
Barkley completed his speedy recovery from a high-ankle sprain that wound up costing him two games. The coaching staff did not have the luxury of easing the team's star player back into action following a 1-4 start to the season, resulting in a season-high 28 combined touches for Barkley in defeat. The 26-year-old performed well on an individual basis given his heavy workload and the fact that he was likely playing at less than full strength Sunday. Assuming the ankle held up fine, the shorthanded Giants figure to continue leaning on Barkley in a divisional matchup against Washington next Sunday.
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Craig Reynolds RB | WAS
Lions' Craig Reynolds: Takes over after Montgomery exits
Reynolds rushed 10 times for 15 yards in Sunday's 20-6 win over Tampa Bay. He added two catches for 28 yards.
David Montgomery (ribs) exited the game in the second quarter while Jahmyr Gibbs (hamstring) was inactive for the second consecutive week. That left Reynolds to lead the backfield, and he found running room to be scarce, though Tampa Bay held Detroit to 1.8 yards per attempt on the ground overall. He also made a few key plays in the passing game, highlighted by a block on Amon-Ra St. Brown's touchdown just before halftime. While that won't help fantasy box scores, it could help keep Reynolds on the field as the lead back for a Week 7 matchup against Baltimore if Montgomery and Gibbs both remain sidelined.
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Rachaad White RB | WAS
Buccaneers' Rachaad White: Held to 38 total yards
White rushed the ball seven times for 26 yards in Sunday's 20-6 win over the Buccaneers. He added three receptions on four targets for 12 yards.
White got the first chance to lead Tampa Bay's backfield, but after picking up only nine yards on his first three carries, the team began to split work between him and Ke'Shawn Vaughn. While that's concerning for White moving forward, he was far more efficient than Vaughn both on the ground and as a pass catcher. That may mean that he hangs onto the lead-back role, but White now has fewer than 50 rushing yards in three of five games this season and has only one total touchdown.
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Ezekiel Elliott RB | LAC
Patriots' Ezekiel Elliott: Scores first New England touchdown
Elliott carried the ball seven times for 34 yards and a touchdown and caught his only target for 15 yards in Sunday's 21-17 loss to the Raiders.
The veteran running back scored his first TD as a Patriot midway through the first quarter on a two-yard run, while Elliott's 34 rushing and 49 scrimmage yards were his second-highest totals of the year. Rhamondre Stevenson left Sunday's game to get checked out for head and ankle injuries before returning and scoring New England's final touchdown of the day, but if he were unable to suit up in Week 7 against the Bills, Elliott could be in line to handle his largest workload of the season.
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Rhamondre Stevenson RB | NE
Patriots' Rhamondre Stevenson: Finds end zone in Vegas
Stevenson carried the ball 10 times for 46 yards and a touchdown and caught five of six targets for 24 yards in Sunday's 21-17 loss to the Raiders.
His one-yard TD plunge late in the fourth quarter brought the Patriots within two points, but the team's final drive ended in disaster when Mac Jones got sacked in the end zone for a safety. Stevenson had exited the game earlier to be checked out for head and ankle injuries, but the fact that the running back was not only able to return but make an impact suggests his status for Week 7 won't be in question. The 70 scrimmage yards represented Stevenson's highest total since New England's opener, while the TD was his first since Week 2.
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Damien Harris RB | BUF
Bills' Damien Harris: Diagnosed with neck injury
Harris has been diagnosed with a neck injury and won't return to Sunday's game against the Giants, Paul Schwartz of the New York Post reports. Harris has movement in his arms and legs after leaving the game in an ambulance.
This early report is encouraging after Harris was stretchered off in a scary scene, but further details will likely emerge after Harris is examined at a Buffalo-area hospital. The running back was injured on his only touch of the game.
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Damien Harris RB | BUF
Bills' Damien Harris: Leaves game in ambulance
Harris was stretchered off the field and loaded into an ambulance in the second quarter of Sunday's game against the Giants, Matt Parrino of Syracuse.com reports.
Harris remained down on the field at the end of a one-yard run. The nature of his injury wasn't immediately clarified, but the running back will be taken to a local hospital for further evaluation. Harris gave a thumbs-up as he was being loaded onto the stretcher.
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D'Andre Swift RB | CHI
Eagles' D'Andre Swift: Scores receiving TD
Swift had 10 carries for 18 yards while adding eight receptions on 10 targets for 40 yards and a touchdown in Sunday's 20-14 loss to the Jets.
Swift was stymied by New York's beefy front on his team-high 10 carries Sunday, but his busy work as a receiver helped offset his shortcomings on the ground. It was the 24-year-old's third touchdown of the season and first via a reception through six games with his new club. Swift had just nine receptions (11 targets) in Philadelphia's first four games before rattling off 14 catches over the last two weeks. The recent influx in targets only boosts Swift's fantasy value heading into next week's game against Miami on Sunday Night Football.
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Chuba Hubbard RB | CAR
Panthers' Chuba Hubbard: Strong showing as lead back
Hubbard carried the ball 19 times for 88 yards and a touchdown in Sunday's 42-21 loss to the Dolphins. He added one reception for two yards.
Hubbard accounted for 19 of Carolina's 25 rushing attempts in the absence of Miles Sanders (shoulder). He delivered consistent gains to keep the offense on schedule and also sprinkled in a long gain of 17 yards as well as a six-yard touchdown run. Hubbard was curiously disregarded as a receiver -- he had multiple targets in every game leading up to Sunday's matchup -- though his rushing volume left little to complain about. Carolina will head into a Week 7 bye, but there's at least a possibility that Hubbard will have the chance to lead the backfield again in a Week 8 matchup against Houston.
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Joe Mixon RB | HOU
Bengals' Joe Mixon: Limited to 62 total yards
Mixon rushed 12 times for 38 yards in Sunday's 17-13 win over Seattle. He added three receptions on four targets for 24 yards.
Despite leading for nearly the entire game, the Bengals ran only 53 offensive plays. Mixon in particular felt the effects of that depressed volume, as he saw a season-low 12 carries. He salvaged his day a bit with work as a pass catcher, as his 24 yards were his second-best mark of the campaign. Through six games, Mixon has yet to surpass 100 total yards in any contest and has topped 70 rushing yards just once.