Jefferson (hamstring) wasn't activated from injured reserve Saturday and won't be available for Sunday's game against the Saints, Tom Pelissero of NFL Network reports.
Head coach Kevin O'Connell tipped his hand about Jefferson's status earlier this week, when he suggested it would be "a little aggressive" for the receiver to play Week 10 when first eligible to return from IR. Though Jefferson was able to practice in a limited fashion this week and had been listed as questionable heading into the weekend, he'll ultimately miss his fifth consecutive game. Jordan Addison and Brandon Powell will likely play prominent roles Sunday, especially if wideout K.J. Osborn (concussion) and tight end T.J. Hockenson (ribs) are unable to suit up. Jefferson's next chance to play will come Week 11 against the Broncos on Nov. 19.