Pickett left Sunday's matchup against Tampa Bay in the second half due to an undisclosed injury, Brooke Pryor of ESPN.com reports.
Pickett took a big hit from Devin White and immediately went to the medical tent. After a brief stint there, he was taken to the locker room. Mitch Trubisky, who started the first four games of the season for Pittsburgh, has replaced Pickett at quarterback.