Pickens recorded one reception on two targets for four yards in Saturday's 9-3 preseason loss to the Bills.
Pickens played with Russell Wilson in Saturday's game after catching passes from Justin Fields in Pittsburgh's first preseason contest. He had a quiet stat line, though the offensive line struggled and failed to give Wilson consistent time to throw. Pickens also narrowly missed out on a highlight reel catch on his final drive, as he was ruled to have not tapped down his second toe as he was falling out of bounds.