Edwards sustained a confirmed torn ACL during Thursday's practice, Adam Schefter of ESPN reports.
Edwards joins J.K. Dobbins as Ravens running backs to suffer such an injury, and Justice Hill also is out for the season with an Achilles tear, leaving the team painfully thin at running back. Ty'Son Williams is expected to step in as Baltimore's lead running back to kick off the campaign, with Trenton Cannon also on the 53-man roster and Le'Veon Bell and Devonta Freeman on the practice squad.