Head coach John Harbaugh said Monday that Isaac had a "setback" with his elbow injury and isn't close to a return from injured reserve, Jeff Zrebiec of The Athletic reports.
Isaac started the season on IR after undergoing surgery on a dislocated elbow that he suffered in mid-August during a preseason game. He was expected to miss only the first half of the 2025 season, but the second-year linebacker will need more time to rehab from his procedure.