Kupp (ankle) has been ruled out for Sunday's game against San Francisco, Gary Klein of the Los Angeles Times reports.
It was only a matter of time, as the conversation surrounding Kupp has been more about injured reserve than his Week 3 availability. The Rams can only bring eight players back from IR all season and have six or seven return candidates on the list already, so they may keep Kupp on the active roster even if he's expected to miss four or more games. The team hasn't specifically commented on that aspect, but coach Sean McVay did say Monday that Kupp is likely out for an "extended period of time."