Kupp, who was placed on the reserve/COVID-19 list Tuesday, won't be available for Sunday's game against the Cardinals, Ian Rapoport of NFL Network reports.
Per Rapoport, Kupp's placement on the list was the result of a positive test, so he won't have sufficient time to make a full recovery from the virus and gain clearance for the weekend. With starting quarterback Jared Goff (thumb) also sidelined, John Wolford will step in under center, throwing passes to a wideout corps headlined Robert Woods, Josh Reynolds and Van Jefferson.