Cunningham (thigh) is inactive for Sunday's Week 5 tilt versus the Bills, the team's official site reports.
The backup running back will take a seat after being limited on Thursday and Friday with the thigh injury he suffered against the Cardinals in Week 4. His absence should open up a handful of reps for rookie Malcolm Brown, who had an impressive preseason, but should also result in an uptick in workload for Todd Gurley.