Jefferson (ankle) rushed four times for seven yards and caught his lone target for one yard in Friday's 16-15 preseason loss to the Bills.
Jefferson didn't find much running room, but at least the rookie seventh-round pick was able to suit up after recently battling an ankle injury. Jamaal Williams got the start with D'Andre Swift (groin) out but managed only 15 yards on nine carries, and Detroit's most effective running back was Craig Reynolds in the fourth quarter. Now healthy, Jefferson should see an expanded role in Week 2 of preseason action against Pittsburgh.