Agnew caught four of five targets for 49 yards, returned three kickoffs for 72 yards and lost a fumble during Sunday's 37-17 loss to Houston.
The 28-year-old played 55 percent of Jacksonville's offensive snaps with Zay Jones (knee) sidelined and operated as the team's No. 3 wideout. Agnew had just one reception in the first two games of the season, and he'll likely return to that lesser role in the offense if Jones is available Week 4.