The Giants have ruled Barkley (ankle) out for Sunday's game against the Raiders, Jordan Raanan of ESPN.com reports.
Though Barkley was activated from the reserve/COVID-19 list Friday after the Giants determined a past test result for the virus was a false positive, he wasn't able to make enough progress in his recovery from a sprained left ankle to put an end to a three-game absence this weekend. Barkley noted prior to the Giants' Week 8 loss to the Chiefs that he experienced some renewed soreness and swelling in the ankle, but with the benefit of a Week 10 bye, the team is likely hoping that the star running back can make it back on the field for a Nov. 22 game in Tampa Bay in Week 11. The Giants will turn to Devontae Booker to handle a lead role out of the backfield once again this weekend versus Las Vegas.