Barkley (ankle) isn't participating in Thursday's practice, Dan Duggan of The Athletic reports.
While the Giants haven't officially ruled Barkley out for Sunday's game against the Rams, the left low-ankle sprain he sustained in last week's loss to Dallas is expected to sideline him for 2-to-3 weeks. Assuming Barkley remains idle for Friday's practice, he'll likely be ruled out for the Week 6 contest shortly thereafter. Devontae Booker is projected to serve as the Giants' lead back against Los Angeles.