Barkley (undisclosed) won't return to Sunday's game in Chicago.
Barkley was injured on the first play of the second quarter, grabbing at his right leg before needing a cart to get to the locker room. Around the time Barkley was ruled out, Pat Leonard of the New York Daily News reported the running back was getting X-rays on his right knee. With Barkley out, the Giants are down to one active RB (Dion Lewis).