Brightwell (neck) has been ruled out for Sunday's game against the Eagles, Dan Salomone of the Giants' official site reports.
Brightwell suffered the neck injury last week against the Cowboys and will be sidelined for at least one game. Saquon Barkley (ankle) and Devontae Booker are the only other running backs on the active roster, so the Giants could add a back from the practice squad for depth purposes this weekend.