Mathews (knee) did not suit up for Friday's practice, Zach Berman of The Philadelphia Inquirer reports.
Mathews will sit out for the second straight day to give his sore knee additional rest. He will have one more opportunity to practice this week with the Eagles playing Monday, and he still has a chance to play in Week 12. However, even if he is able to get on the field, he could cede a chunk of his workload to Darren Sproles and/or Wendell Smallwood.