Sanders was estimated as a non-participant on Wednesday's practice report due to a quadriceps injury.
Sanders previously has dealt with ankle issues this season, so this quad concern is a new one for the third-year running back. He is coming off back-to-back 100-yard efforts on the ground against the Jets and Washington in which he combined for 47 touches for 288 yards from scrimmage. The Eagles may be managing Sanders' activity due to the recent heavy workload, but his listing on their last two injury reports of Week 16 prep may provide some insight into his potential to play (or not) Sunday against the Giants.