Gainwell was a limited participant in Wednesday's practice due to an ankle injury.
Fellow running backs Jordan Howard (neck) and Miles Sanders (hand) both missed practice, with the latter already having been ruled out for Sunday's game against Washington. Boston Scott will likely operate as the Eagles' lead runner if Howard is also out, but Gainwell could also have a significant role, assuming his ankle injury is minor. His ability to practice in any capacity Wednesday suggests that's likely the case.