Mack rushed 28 times for 101 yards while securing two of five targets for eight yards across six appearances in 2021.
The 25-year-old began the 2021 campaign as the Colts' No. 3 running back behind Jonathan Taylor and Nyheim Hines, but he saw limited playing time early in the season. Mack and the Colts mutually agreed to seek a trade in late September, but a trade partner wasn't found. The 2017 fourth-rounder didn't appear in any of the final nine games of the season, mainly due to being a healthy scratch. Mack is slated to become an unrestricted free agent during the offseason, and it wouldn't be surprising to see him attempt to carve out a role elsewhere.