Coach Shane Steichen said Friday that Downs (ankle) is out for Sunday's season opener against the Texans.
Downs was able to do some individual movement drills off to the side during Friday's practice, but he won't be ready for Week 1 action and thus will target a potential return Sunday, Sept. 15 against the Packers. In Downs' absence versus Houston, fellow WRs Adonai Mitchell and Alec Pierce should see added opportunities behind No. 1 receiver Michael Pittman.