Downs (ankle) isn't practicing Wednesday, Nate Atkins of The Indianapolis Star reports.
Downs hasn't practiced since suffering a high-ankle sprain Aug. 7, which was 32 days before the Colts' Sept. 8 season opener against Houston. Head coach Shane Steichen said Sunday that he's hopeful Downs will be available for the season opener, but the wideout's continued absences from practice suggest he's in danger of sitting out. Alec Pierce and Adonai Mitchell both had full-time roles on the first-team offense this preseason alongside No. 1 receiver Michael Pittman.