Wilkins (ankle) has been ruled out for Sunday's contest against the Jaguars due to a knee injury, Andrew Walker of the Colts' official site reports.
Wilkins was added to the injury report Thursday with an ankle issue, but it was a knee concern that limited his participation in practice Friday and prompted the Colts to hold him out of the season finale, With Wilkins sidelined, Nyheim Hines and Jonathan Williams could be in line to handle additional snaps behind top running back Marlon Mack.