Mitchell could see additional targets Sunday against the Texans, as JJ Stankevitz of the Colts' official site reports that Josh Downs (ankle) has been ruled out.
Mitchell's likely to play primarily in the slot, but there will likely be more opportunities for both the rookie second-round draft pick and Alec Pierce alongside Michael Pittman in Downs' absence. Mitchell showed promising chemistry with quarterback Anthony Richardson as they connected for a touchdown in the preseason finale, and they will look to carry that success over into the regular season.