Edwards-Helaire suffered a sprained MCL in Sunday's loss to the Bills, Ian Rapoport of NFL Network reports.
Edwards-Helaire was carried off the field after he suffered his injury Monday but was able to walk gingerly to the locker room under his own power. The 22-year-old is expected to miss a few weeks due to his injury, while Darrel Williams and Jerick McKinnon should handle increased work in his absence.