Edwards-Helaire (undisclosed) has been placed on the active/physically unable to perform list, Tom Pelissero of NFL Network reports.
Added clarity on what injury or issue Edwards-Helaire is dealing with could come as soon as Wednesday, when coach Andy Reid is slated to address reporters, per Herbie Teope of The Kansas City Star. With Edwards-Helaire sidelined, Ronald Jones, Jerick McKinnon, Isiah Pacheco, Derrick Gore and Tayon Fleet-Davis are available to handle Kansas City's backfield reps.