The Chargers placed Ekeler on the reserve/COVID-19 list Wednesday after he tested positive for the virus, Ian Rapoport of NFL Network reports.
Reports surfaced Monday suggesting that Ekeler was headed to the list, but it wasn't until Wednesday that the running back was officially deactivated. According to Daniel Popper of The Athletic noted Monday that Ekeler is day-to-day, which suggests that he's vaccinated and therefore has a chance to play Sunday in Houston if he can test out of the NFL's COVID-19 protocol. If not, Justin Jackson would be the top candidate to replace Ekeler as the Chargers' lead back.