Ekeler (ankle) isn't practicing Wednesday, Adam Schefter of ESPN.com reports.
Head coach Brandon Staley said Monday that there's "no timeline" for Ekeler's return from the ankle injury that kept him out for this past Sunday's loss to the Titans, so it's no surprise that the star running back isn't practicing Wednesday. If Ekeler isn't ready to play this weekend at Minnesota, Joshua Kelley would be in line to handle the majority of backfield touches against a Vikings defense that allowed 259 rushing yards to the Eagles in Week 2.