Sampson is questionable to return to Sunday's matchup against San Francisco due to a calf injury.
Sampson's injury was announced by Cleveland in the third quarter. Prior to exiting, he rushed four times for 23 yards. If Sampson is unable to return, Jerome Ford could see more offensive snaps behind lead back Quinshon Judkins, while Malachi Corley could serve as the team's lead kick returner.