Breida is set to serve as the No. 2 running back behind Devin Singletary with Zack Moss listed as inactive for the Week 1 matchup against Pittsburgh.
In one of the bigger surprises of Week 1, Moss looks to be a healthy scratch in Buffalo, leaving Breida open for a potentially larger role than most expected headed into the season. Breida logged 254 rushing yards on 59 attempts in an injury-shortened 2020 season with Miami and is well accustomed to serving as a change-of-pace back, as that was his role through his first three seasons in the league with San Francisco.