Herron's teammates LeSean McCoy and Karlos Williams have both officially been ruled out for Sunday's game in Tennessee.
Anthony Dixon will get first crack at the Titans and their 22nd-ranked run defense, however the folks running the Bills have made statements this week that they won't be afraid to use Herron. He's familiar with offensive coordinator Greg Roman and had some success at times last season with the Colts around their running game issues elsewhere.