Mixon (ankle) was spotted off to the side during Thursday's practice and is set to go down as a non-participant, James Rapien of SI.com reports.
Though head coach Zac Taylor said Mixon was moving around well after practicing on a limited basis Wednesday, the running back's inability to join his healthy teammates on the field a day later isn't the most encouraging sign for his availability this weekend in Detroit. While managing the ankle injury ahead of last week's loss to the Packers, Mixon saw a light workload, playing only 18 snaps while getting 11 touches (10 carries, one reception). Fantasy managers may have been hoping Mixon would be ready to handle his normal three-down duties this weekend, but his absence from practice Thursday suddenly leaves his ability to do that in question.