Mixon (ankle) wasn't seen at the early portion of Friday's practice, Ben Baby of ESPN.com reports.
MIxon looks like he'll sit out practice for the third consecutive day due to the ankle sprain, making it difficult to envision him being available for Sunday's matchup with the Packers. Assuming Mixon ends up being ruled out for the Week 5 matchup, Samaje Perine should take over the starting role, with Chris Evans handling the third-down role.