Lance sustained a severe right ankle injury Sunday against the Seahawks that's expected to require season-ending surgery, Adam Schefter of ESPN reports.
Lance was carted off the field with an air cast on his lower right leg in the first half of the 49ers' Week 2 contest. He was quickly ruled out, and now it appears he won't play again this season. With Lance sidelined, the team will turn to Jimmy Garoppolo under center.