Draughn (knee) won't take part in practice Wednesday.
Draughn hasn't practiced since suffering a sprained knee in Week 15 versus the Bengals, but two opportunities await before week's end to make his presence felt. If he's ultimately ruled out or doesn't play Sunday against the Rams, the 49ers will likely employ a running back tandem of DuJuan Harris and Jarryd Hayne, as they did this past Sunday in Detroit.