Okuayinonu finished the 2025 regular season with 39 tackles (23 solo), including 3.0 sacks, and a forced fumble across 15 active games.
Okuayinonu signed a one-year contract to return to the 49ers and serve as a backup edge rusher. The 27-year-old was afforded some extra run following DE Nick Bosa's severe knee injury early in the campaign. Okuayinonu finished with numbers similar to his solid run as a reserve in 2024, so it wouldn't be surprising to see San Francisco bring back the unrestricted free agent for a third season in 2026.