Breida (ankle) will be held out of Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
In the midst of a 1-to-2-week recovery effort from a low-ankle sprain, Breida has yet to get on the practice field since suffering the injury Week 10. As long as Breida remains sidelined, Raheem Mostert will serve as the main change-of-pace option to Tevin Coleman out of the 49ers' backfield.